IndraLab

Statements


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sparser
"In vitro studies together with work in non-neuronal cells demonstrated that CALM potently binds to clathrin via a series of degenerate motifs."

reach
"AP180 (and the related protein CALM) binds directly to clathrin but also contains a copy of the epsin amino-terminal homology (ENTH) domain [35]."

sparser
"The CALM protein binds clathrin and regulates clathrin-mediated endocytosis through its ability to regulate the orderly progression of clathrin-coat formation ( xref ; xref )."

sparser
"Previous studies have shown that SMAPs interact with clathrin and CALM, modulating clathrin-coated vesicle formation on the TGN ( xref ; xref ; xref )."

sparser
"Clathrin-CALM interaction seems to be regulated by multiple contact interfaces."

reach
"Both AP180 and CALM bind AP-2 and clathrin."

sparser
"C-terminal fragments approximating the AD, human CALM 414-652 [ xref ] or 256-652 [ xref ], can bind clathrin similar to the full length sequence, but sequences with a truncated C-terminus, i.e. , 1-413, 414-613 [ xref ] or 256-583 [ xref ] bind clathrin poorly."

sparser
"Thus, the entire AD is required for efficient clathrin binding by CALM in vitro and in vivo ."

sparser
"To examine the interaction of truncated CALM with clathrin, we cloned CALM ending at breakpoint 1926 or breakpoint 2091, with or without exon 13, which encodes a DPF motif that binds the endocytic adaptor AP2."

sparser
"Interestingly, however, endocytosis may be more efficient when targeting multiple receptors associated with CAM-mediated and clathrin-mediated endocytosis, rather than targeting multiple receptors associated solely with CAM-mediated endocytosis."