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USP8 increases the amount of CD274. 8 / 8
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"The findings showed that USP8 overexpression resulted in no change in PD-L1 mRNA level, decreased ubiquitination level of PD-L1, and increased protein level of PD-L1 (P < 0.05, Fig. 7B–D)."
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"Flow cytometry showed that USP8 deficiency reduced PD-L1 expression and increased MHC-1 expression, which was also confirmed in vitro (Fig. 6d–g; Fig. S10a, b)."
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"However, a more nuanced study yielded contrary results, indicating that targeting USP8 elevates PD-L1 expression."
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"By contrast, USP8 overexpression upregulated PD-L1 levels (Fig. S7d, e)."
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"Our findings from the present study revealed that lncRNA SNHG12 improves mRNA stability and expression of PD-L1 and USP8, and USP8-mediated deubiquitination increases the protein level of PD-L1, resulting in the subsequent enhancement of immune escape in NSCLC (Fig. 10)."
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"Mechanically, the binding of lncRNA SNHG12 to HuR improved mRNA stability and expression of PD-L1 and USP8, and USP8-mediated deubiquitination stabilized the protein level of PD-L1."
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"We inferred that USP8 could potentially regulate the protein level of PD-L1 through deubiquitination."
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"Furthermore, it has been demonstrated that USP8 deficiency induced a time- and dose-dependent decrease in the PD-L1 protein level and increased the amount and function of tumor-infiltrated activated T cells [61]."
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