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OTUD3 inhibits ferroptosis. 4 / 4
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"In vivo, after overexpressing OTUD3 and knocking down IRP2, we found that overexpression of OTUD3 promoted IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway."
39415292
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"Overexpression of OTUD3 induced IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway."
39415292
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"Finally, through in vivo experimental verification, we verified the mechanism of this new pathway in IS; namely, overexpression of OTUD3 induced IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway.In conclusion, we preliminarily evaluated the effects of the OTUD3/IRP2/p53/PTGS2 pathway on IS and determined whether its potential mechanism of action was related to ferroptosis."
39415292
reach
"These results suggested that the overexpression of OTUD3 induced IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway."
39415292