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OTUB1 activates JAG1. 5 / 5
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"The EdU incorporation assay demonstrated that OTUB1 silencing dramatically reduced the EdU positive cells in AGS and MKN28 cells (Fig. 3C, D)."
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"We further analyzed the Hippo target gene expression in OTUB1 depleted conditions, in which OTUB1 silencing could inhibit Hippo target gene expression in AGS and MKN28 cells, including CTGF and CYR61 (Fig. 2C)."
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"The luciferase reporter assay showed that OTUB1 inhibition could inhibit TEAD response elements activity in AGS and MKN28 cells (Fig. 2D)."
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"The CCK8 assay showed that OTUB1 depletion inhibited cancer cell proliferation in AGS and MKN28 cells (Fig. 3A, B)."
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"While in the wound-healing assay, we found that OTUB1 depletion inhibited wound closure speed in both AGS and MKN28 cells (Fig. 3I, J)."
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