IndraLab

Statements

Berberine inhibits KCNH2. 8 / 8
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"XREF_BIBR Similarly, the antidiarrheal berberine and its derivative, dihydroberberine (XREF_FIG), have been shown to impair hERG folding in both HEK293 cell lines and guinea pig ventricular cardiomyocytes."
33763655
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No evidence text available
30086269
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"HERG1 is involved in the pathophysiological process and inhibited by berberine in SKOV3 cells."
31186788
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"(2) The combination of Berberine with Azithromycin reduced hERG currents, producing an inhibitive effect stronger than use of a single drug alone, due to the high binding affinity for the onset of inactivation."
25976224
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"These results indicate that berberine in combination with statins can increase cardiotoxicity by inhibiting CYP3A4 and hERG channel."
30086269
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"Together these findings indicate that berberine preferentially blocks the open state of hERG channels by interacting with specific residues that were previously reported to be important for binding of more potent antagonists."
16424781
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"Berberine was proved to reduce hERG membrane stability by disrupting caveolin-1."
33867974
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"Berberine blocked the HERG channels potently with an IC50 value of approximately 75 micromol/L."
11741516