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Berberine inhibits KCNH2. 15 / 16
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"XREF_BIBR Similarly, the antidiarrheal berberine and its derivative, dihydroberberine (XREF_FIG), have been shown to impair hERG folding in both HEK293 cell lines and guinea pig ventricular cardiomyocytes."
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"Therefore, the dose administered must be clinically observed to avoid the negative effects caused by high plasma drug concentrations.According to previous study, the date appear to suggest that berber[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It was also confirmed that berberine could inhibit hERG currents by accelerating the onset of inactivation."
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"Berberine was earlier described to inhibit hERG potassium current in HEK cells expressing hERG channels [8] , to block I Kr current in cardiac myocytes [6] , and to increase action potential duration [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Berberine in combination with these two statins could inhibit hERG currents more severely, but the mechanism of berberine co-administered with statins on hERG currents is not well characterized."
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"The present study showed that combined utilization of berberine and statins decreased hERG currents more seriously by accelerating channel inactivation than berberine alone."
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"HERG1 is involved in the pathophysiological process and inhibited by berberine in SKOV3 cells."
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"(2) The combination of Berberine with Azithromycin reduced hERG currents, producing an inhibitive effect stronger than use of a single drug alone, due to the high binding affinity for the onset of inactivation."
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"Berberine was proved to reduce hERG membrane stability by disrupting caveolin-1."
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"Berberine has been shown to promote the degradation of and directly inhibit the cardiac human hERG channels, and may thus prolong the QT interval."
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"Berberine blocks hERG channels and prolongs action potential duration [ 14 ]."
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"According to the results of our research group, berberine blocks open-channel hERG channels with an IC50 of 3.1 ± 0.5 μM [ 18 ]."
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"Therefore, taking berberine in vivo can strongly inhibit hERG channel, which may lead to cardiotoxicity.It is well known that statins such as simvastatin and atorvastatin are widely used in the treatm[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Together these findings indicate that berberine preferentially blocks the open state of hERG channels by interacting with specific residues that were previously reported to be important for binding of more potent antagonists."
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"Berberine blocked the HERG channels potently with an IC50 value of approximately 75 micromol/L."
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