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USP22 increases the amount of USP22. 4 / 4
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"In HG-treated NRK-52E cells, USP22-FLAG overexpression further increased USP22 expression ( Fig. 3 C), downregulated E-cadherin and ZO-1expression, and upregulated Vimentin expression ( Fig. 3 D)."
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"The LSL Usp22 allele inserted at the Rosa26 locus allows tissue-specific overexpression (OE) of USP22 upon exposure to Cre recombinase [17]."
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"USP22 knockdown (Figure 3A) by using siRNA (si-USP22) dramatically decreased USP22 level and, in parallel, the levels of cyclin D1 and of cell vitality (Figure 3B) and viability (Figure 3C) compared with the negative control."
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"It was identified that USP22 siRNA decreased the expression of USP22 protein (Fig. 2A) and also inhibited cell growth in OSCC cells (Fig. 2B)."
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