IndraLab

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UCHL1 activates cell growth. 10 / 10
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"We found that knockdown of UCHL1 in higher-UCHL1-expression MG63 cells significantly reduced cell growth rate and promoted cell apoptosis."
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"The observation that in lymphoma cells, UCHL1 knockdown decreases cellular growth and viability, may in the future contribute to evolvement of novel therapies [12,17,36] ."
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"While exploring the mechanism by which UCH-L1 promotes cell growth and survival in B-cell malignancies, we observed a striking effect of UCH-L1 on the Akt signaling pathway."
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"UCHL1 overexpression could induce cell growth arrest in prostate, hepatocellular and breast cancer by stabilizing p53 [16, 20, 21]."
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"Compared with other members, UCHL1 was the most potent candidate by MTT assay, in which UCHL1 knockdown led to a substantial decrease in cell growth (Fig. 1G)."
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"UCHL1 over-expression has been reported to induce cell growth arrest in prostate cancer XREF_BIBR and breast cancer XREF_BIBR, XREF_BIBR."
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"A role for UCHL1 in proliferation is consistent with the pro oncogenic functions of UCHL1 in various cancers [34] and the findings that in lymphoma cells UCHL1 knockdown decreases cellular growth and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCHL1 is notably expressed in NEPC and SCLC, promotes cell growth in NEPC (NCI‐H660), NE‐like (DU145), and SCLC (NCI‐H82) cancer cell line, and upregulates NE signatures in CRPC‐adeno (22RV1) cell line in vitro."
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"The vitro experiments showed that over-expression of UCHL1 in osteosarcoma cancer cells promoted cell growth and metastasis, and inhibited cell apoptosis."
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"Overexpression of WT UCHL1 enhanced cell growth, as measured by colony formation ability (Figures 2B and S2I), whereas loss of UCHL1 in NEPC cells decreased their clonogenic potential (Figures 2C and S2I)."
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