IndraLab

Statements

CYLD inhibits autophagy. 11 / 12
| 1 10
eidos
"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [ 26 ] ."
34336031
reach
"Our findings highlight a unique role of CYLD in suppressing autophagy at the step of autolysosome efflux in pressure overloaded hearts and suggest that targeting CYLD may be a novel therapeutic approach for the treatment of adverse cardiac remodeling and dysfunction associated with hypertensive heart disease."
32553594
reach
"In addition, we found that an inhibitor of the Wnt/β-catenin pathway (PKF115-584) reversed the CYLD knockdown-induced activation of the Wnt/β-catenin pathway and impair autophagy to increase the expre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34774660
reach
"In the present study, we demonstrated that CYLD suppresses autophagy at the stage of autolysosome efflux in cardiomyocytes, thereby exaggerating cardiac pathological remodeling and dysfunction in the setting of PO."
32553594
reach
"Mechanistically, CYLD suppresses autophagy by selectively interrupting autolysosome efflux in cardiomyocytes, thereby switching autophagic adaptation into autophagic damage in PO-hearts."
32553594
reach
"Indeed, our results demonstrate that upregulation of CYLD in cardiomyocytes impairs autophagy at the stage of autolysosome efflux and enhances myocardial death in PO-hearts."
32553594
reach
"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [XREF_BIBR]."
34336031
reach
"79 In bladder cancer, CXCL12 upregulates the deubiquitinating enzyme CYLD through the JAK2/STAT3 signalling pathway, and CYLD inhibits autophagy in bladder cancer by inducing the accumulation of P62 through deubiquitination of P62."
38506082
reach
"CYLD suppresses autophagy at a stage of autolysosome efflux in cardiomyocytes."
32553594
reach
"These results suggested that PA upregulated CYLD impair autophagy to accumulate p62 through inactivation of the Wnt/β-catenin pathway in NRCMs."
34774660
reach
"Noteworthy, CYLD also inhibited autophagy of Listeria in a RIPK2-ERK1/2-dependent manner."
26834734