IndraLab

Statements

CYLD inhibits autophagy. 8 / 9
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"Indeed, our results demonstrate that upregulation of CYLD in cardiomyocytes impairs autophagy at the stage of autolysosome efflux and enhances myocardial death in PO-hearts."
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"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [XREF_BIBR]."
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"CYLD suppresses autophagy at a stage of autolysosome efflux in cardiomyocytes."
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"Mechanistically, CYLD suppresses autophagy by selectively interrupting autolysosome efflux in cardiomyocytes, thereby switching autophagic adaptation into autophagic damage in PO-hearts."
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"Noteworthy, CYLD also inhibited autophagy of Listeria in a RIPK2-ERK1/2-dependent manner."
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"In the present study, we demonstrated that CYLD suppresses autophagy at the stage of autolysosome efflux in cardiomyocytes, thereby exaggerating cardiac pathological remodeling and dysfunction in the setting of PO."
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"Our findings highlight a unique role of CYLD in suppressing autophagy at the step of autolysosome efflux in pressure overloaded hearts and suggest that targeting CYLD may be a novel therapeutic approach for the treatment of adverse cardiac remodeling and dysfunction associated with hypertensive heart disease."
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"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [ 26 ] ."
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