IndraLab

Statements

Modified SCN1A decreases the amount of Gadd45gamma. 3 / 3
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"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced the expression of Gadd45gamma, which interacted with Gadd45gip1."
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"Thus, the findings based on both NAC-1 knockdown and N130 mut approaches indicated that NAC-1 expression and homodimerization were essential to suppress Gadd45gamma expression."
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"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced expression of Gadd45gamma which interacted with Gadd45gip1."
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