IndraLab

Statements


Modified SCN1A decreases the amount of Gadd45gamma. 2 / 2
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"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced expression of Gadd45gamma which interacted with Gadd45gip1."

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"Thus, the findings based on both NAC-1 knockdown and N130 mut approaches indicated that NAC-1 expression and homodimerization were essential to suppress Gadd45gamma expression."