IndraLab

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MYC activates USP10. 3 / 3
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"OIS can increase the stability of p53 through p14 , which in turn is stabilised by oncogenic c-MYC transcriptionally upregulating USP10."

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"Aram et al. reported that c-Myc was a transcriptional activator of USP10 that bound to the second E-box upstream of the USP10 transcription start site ."

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"Our studies indicate that USP10 induced by c-Myc has a crucial role in OIS by maintaining the stability of key tumor suppressor p14ARF."