IndraLab

Statements

MYC inhibits USP28. 3 / 3
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"To demonstrate that, we next sought to determine if reexpressing c-MYC could rescue USP28 depletion."
34822842
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"Indeed, HIF increases MYC phosphorylation at Thr58, triggering MYC ubiquitination, and decreases the de-ubiquitinating enzyme USP28, promoting MYC proteasome dependent degradation [XREF_BIBR]."
28040803
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"Here we show that dimerization of USP28 limits deubiquitination of MYC, thereby controlling interactions with PAF1c."
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