IndraLab

Statements

USP25 activates TNF. 5 / 5
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"Consistently, Usp21 deficiency resulted in production of more IFNbeta and TNF in MEFs and BMDMs in response to HSV-1 infection (XREF_FIG)."
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"Notably, Usp21 fl/fl Lyz2-cre mice produced significantly higher concentrations of IFNbeta, IL-6, and TNF in serum upon HSV-1 infection compared with infected control mice (XREF_FIG)."
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"In addition, double immunofluorescence staining confirmed that USP25‐deficient microglia produced more TNF‐α than USP25‐sufficient microglia in vivo after transient MCAO (Figure 2J)."
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"Upon stimulation with LPS, USP25 BV2 cells produced significantly more TNF‐α, IL‐6, and IL‐1β than USP25‐sufficient control cells (Figure 5A–C)."
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"As compared with WT microglia, USP25 primary microglia produced significantly more TNF‐α, IL‐6, and IL‐1β in response to LPS (Figure 5D–F), in line with the results obtained with BV2 cells."
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