IndraLab

Statements

Calcium(2+) activates CACNA1H. 4 / 4
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"The GAERS Ca v 3.2 mutation produces an arginine to proline (R1584P) substitution in exon 24 of Cacna1h, encoding a portion of the III-IV linker region in Ca v 3.2."
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"PMA treatment of Ca V 3.2-HEK293 cells for 1 h upregulated I Cav3.2 by 51.0 ± 1.6% ( n = 5) at the level of maximum peak current ( Figs."
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"The proliferation of MCF-7 cells is also inhibited by the T-type Ca 2+ channel blockers NNC-55-0396 and mibefradil, as well as by siRNA-mediated knockdown of Cav3.1 and Cav3.2 channels [26,27] ."
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"Gain-of-function mutations in CACNA1H increase calcium influx and increased aldosterone production (153)."
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