IndraLab

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Luteolin inhibits FURIN. 5 / 5
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"Our findings suggest that luteolin inhibition of furin may occur at host and pathogen interface that permits the virus to escape the suppression by mutating key residue that may lead to an altered interface."
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"We previously showed that luteolin, a well-known plant derived component found in the " heat clearing " class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 muM) of the host proprotein convertase furin, an endoprotease that is required for maturation of flaviviruses in the trans-Golgi compartment."
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"Luteolin as another natural compound inhibited DENV replication by blocking the later phase of DENV viral lifecycle in infected cells (Peng et al., 2017) and inhibiting the cellular proprotein convertase furin viral NS3 protease (Peng et al., 2018)."
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"Luteolin also inhibited furin proteins which breakdown the S protein in SARS-CoV."
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"Luteolin inhibits furin proteins which are known to be some of the enzymes that break down the S protein of SARS-CoV , as reported in the Middle East respiratory syndrome ( MERS ) [ 114 ] ."
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