IndraLab

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Luteolin inhibits FURIN. 11 / 11
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"The pre-membrane E protein of DENV is cleaved by furin in the TGN to produce infectious mature viral particles, and luteolin can inhibit the activity of furin, thereby restricting the viral maturation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Luteolin inhibits furin proteins which are known to be some of the enzymes that break down the S protein of SARS-CoV , as reported in the Middle East respiratory syndrome ( MERS ) [ 114 ] ."
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"Luteolin also inhibited furin proteins which breakdown the S protein in SARS-CoV."
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"We found that luteolin inhibited the later stages of dengue viral lifecycle in cells likely by inhibiting the host proprotein convertase furin in an uncompetitive mode, resulting in inefficient cleava[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given our previous demonstration that luteolin weakly inhibits furin and the viral protease, the site of appearance of the two mutations seem to correlate with the biochemical studies so we examined t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand the furin cleavage of WT and SM2 immature viruses were blocked by 50 μM luteolin, while SM1 was still slightly susceptible to furin cleavage."
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"Luteolin as another natural compound inhibited DENV replication by blocking the later phase of DENV viral lifecycle in infected cells (Peng et al., 2017) and inhibiting the cellular proprotein convertase furin viral NS3 protease (Peng et al., 2018)."
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"Peng et al. [139] found that luteolin disrupted the late life cycle of intracellular dengue virus by inhibiting furin in a non-competitive mode, resulting in inefficient cleavage of precursor membrane (prM) proteins and production of less mature viral particles, thereby effectively reducing or preventing subsequent viral infections."
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"Our investigations suggest that resistance against luteolin inhibition of furin is achieved probably through modulating binding interface between furin and prM and possible epistatic interaction with [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Coincidently, these two mutations indirectly corresponded to our previous finding that luteolin was an uncompetitive inhibitor of host protease furin as well as a weak noncompetitive inhibitor of vira[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the double mutant (DM) virus, replication fitness is restored to WT levels in comparison with the attenuation seen in SM1 and increased fitness noted in SM2 suggesting that there may be epistatic i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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