IndraLab

Statements

USP15 activates KEAP1. 3 / 3
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"The authors also suggested that USP15 promotes adipogenesis because the overexpression of USP15 protects a CRL component, Keap1, from autoubiquitination [42,43]."
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"The expression of TIFAB in HSCs allows the signaling of USP15 to different substrates, including MDM2 and KEAP1, leading to a decrease in TP53 expression, which may consequently promote leukemic transformation."
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"circADAM9 targets miR-545-3p, which enhances the expression of the deubiquitinating enzyme USP15, activates the Keap1/Nrf2 pathway and leads to a more severe onset of fibrosis 171."
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