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Calcium(2+) activates KCNK18. 19 / 24
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"Combined extracellular application of calcium (2 mM) and the calcium-ionophore ionomycin (1 microM) activated TRESK current by 50 +/-12% (n = 6, gray control curves, XREF_FIG, for further comments on this stimulation see XREF_SUPPLEMENTARY)."
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"These data indicate that TRESK is activated by increased cytoplasmic calcium concentration."
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"TRESK is activated by the elevation of cytoplasmic calcium concentration via calcineurin in HEK293 cells."
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"Thus, it could support a more robust and sustained Ca 2+ signal, via a positive feedback loop as TRESK and CRAC may support each other 's activity mutually : TRESK activation by Ca 2+ - Cn and CRAC activation by TRESK mediated hyperpolarization."
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"However, TRESK channel is blocked by Ca channel blockers."
29973548
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"The unique calcium dependent activation of TRESK relies on the long cytoplasmic loop of the channel, a distinguishing structural element in the K2P family XREF_BIBR."
24830385
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"Intracellular Ca 2+ -induced activation of the TRESK channel is regulated by interaction with calcineurin and 14-3-3eta [XREF_BIBR XREF_BIBR]."
27790056
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"TRESK is activated by calcium involving the calcium/calmodulin-dependent protein phosphatases in cell models and has been suggested being the target of the Sichuan pepper ingredient sanshool in sensory neurons [64]."
25551770
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"We reasoned that glutamate induced Ca 2+ entry and depolarisation should activate TRESK, since uniquely TRESK is the only K2P with a calcium sensing domain."
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"TRESK is activated in a complex manner by intracellular calcium signalling."
23848401
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"Unlike other K2P channels, TRESK is activated by the calcium signal in heterologous expression systems."
22115960
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"Elevation of the cytoplasmic Ca 2+ concentration activates TRESK."
29763475
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"An increase in the Ca influx by ionomycin, an effective Ca ionophore, activates the TRESK channel [4]."
29973548
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"We did not explore further the change in the calcium pattern, but it is tempting to speculate that the TRESK activation by Ca /calcineurin might limit depolarization and Ca influx, thus preventing excessive neuronal activation."
28937579
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"Since calcium mediated calcineurin activation has previously been shown to activate TRESK 5, we propose that TRESK is an essential component of the negative feedback regulation of glutamate receptor associated calcium influx."
32929069
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"If the TRESK channel is affected by extracellular Ca levels, a blockade of the Ca influx through Ca channels will inhibit the activity of the TRESK channel."
29973548
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"We first assumed that Ca channel blockers could inhibit TRESK activity, because it is known that the TRESK channel is activated by an increase in [Ca ] [1,2]."
29973548
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"In contrast to other K 2P channels expressed in sensory neurons, TRESK is activated by intracellular calcium increases through calcineurin, thus acting as a " brake " to prevent excessive activation of sensory neurons in response to depolarizing stimuli."
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"Cloxyquin activates TRESK in its resting state, by a mechanism independent of Ca /calcineurin-mediated dephosphorilation."
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