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USP22 increases the amount of HIF1. 2 / 2
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"Thus, we further analyzed the effect of USP22 on HIF-1α and confirmed that ubiquitin binding to HIF-1α was significantly reduced after USP22 overexpression in HCC cells, suggesting that USP22 enhances[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Subsequently, USP22 promotes HIF-1α protein levels by deubiquitinating and facilitating the transcription of glycolytic enzymes, thereby promoting tumor progression and glycolysis in HCC."
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