IndraLab

Statements

UCHL1 activates Proteasome. 2 / 2
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"The first study to show the effect of PDE inhibition on UPS mediated degradation of disease related proteins [XREF_BIBR, XREF_BIBR] demonstrated that administration of either rolipram (a selective PDE4 inhibitor) or purified cell-permeable Uch-L1 (ubiquitin C-terminal hydrolase L1) led to proteasome mediated degradation in a mouse model of Alzheimer 's-related amyloid deposition [XREF_BIBR]."
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"Conversely, pharmacological inhibition of UCH-L1 activity resulted in decreased levels of monomeric ubiquitin and decreased rates of proteasome mediated degradation."
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