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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 activates Proteasome. 2 / 2

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"The first study to show the effect of PDE inhibition on UPS mediated degradation of disease related proteins [XREF_BIBR, XREF_BIBR] demonstrated that administration of either rolipram (a selective PDE4 inhibitor) or purified cell-permeable Uch-L1 (ubiquitin C-terminal hydrolase L1) led to proteasome mediated degradation in a mouse model of Alzheimer 's-related amyloid deposition [XREF_BIBR]."

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"Conversely, pharmacological inhibition of UCH-L1 activity resulted in decreased levels of monomeric ubiquitin and decreased rates of proteasome mediated degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...