IndraLab

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Hydroxychloroquine inhibits INS. 21 / 21
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"By increasing the intracellular pH, Hydroxychloroquine inhibits various insulin degrading enzymes [XREF_BIBR] and thus inhibits insulin degradation [XREF_BIBR]."
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"HCQ inhibits the degradation of insulin enhancing the metabolic effects of the hormone to improve insulin sensitivity [44]."
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"HCQ inhibits the degradation of insulin, which enhances the metabolic effects and improves insulin sensitivity [56]."
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"HCQ seemed to decrease insulin resistance and incidence of CVD, but data were too few for meta-analysis."
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"Hydroxychloroquine has been reported to reduce insulin requirements in refractory type II diabetes by an average of 30%."
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"Hydroxychloroquine was found to significantly reduce insulin metabolism in the cytosolic fraction of livers of both healthy and diabetic animals."
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"Hydroxychloroquine decreases insulin degradation at the cellular level , increases intracellular insulin accumulation , and stimulates insulin-mediated glucose transport [ 27 ] ."
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"More recently, Qiao and co-researchers found that pre-treatment of HCQ (40 mg/kg/day) via intraperitoneal injection to male C57BL/6J mice before subjected the animals with high-fat diet significantly reduced intraperitoneal glucose tolerance test (IPGTT), insulin, insulin tolerance test (ITT), HOMA-IR as well as increased homeostatic model assessment for insulin sensitivity (HOMA-IS) and glucose uptake in HepG2 cells [29] ."
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"Hydroxychloroquine in lupus patients, reduces disease activity, cardiovascular risk, insulin resistance, thromboembolic events, infection risk and mortality XREF_BIBR - XREF_BIBR, and this drug should not be discontinued during the perioperative period."
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"The metabolic effect of HCQ is reducing dissociation of insulin from its receptor (tyrosine kinase) and increase the biologic half-life of insulin receptor complex which prolongs the action of insulin [16]."
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"When HCQ was combined with insulin for 6 months, the glycated hemoglobin decreased significantly compared to placebo, and the insulin dose had to be reduced by 30% in the HCQ group [41]."
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"Data from experimental models [XREF_BIBR] and a case report [XREF_BIBR] suggest that chloroquine, but not HCQ, may decrease insulin clearance."
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"Thus, hydroxychloroquine therapy in COVID-19 may lead to hypoglycemia since this drug reduces insulin degradation and improves insulin storage with augmentation of peripheral glucose metabolism (59)."
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"Indeed, in patients with SLE, hydroxychloroquine reduces disease activity, CV risk, insulin resistance and thromboembolic events; therefore, in the perioperative period, it should not be discontinued and could even be protective [XREF_BIBR - XREF_BIBR]."
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"HCQ improves insulin sensitivity and reduces insulin degradation [ 27 ] ."
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"HCQ inhibits the degradation of insulin , which enhances the metabolic effects and improves insulin sensitivity [ 56 ] ."
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"Subsequently, another group of researchers pointed out that oral treatment with HCQ (6.5 mg/kg/day) for 12 weeks lowered FBG, OGTT, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and raised β-cell function in rats fed with high-fat diet containing 46% fat, 20.3% protein, and 24% carbohydrate."
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"The use of hydroxychloroquine improved lipid profiles and reduced incident diabetes and CVD as well as insulin resistance in RA [XREF_BIBR]."
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"This would imply that HCQ reduces clearance of insulin, and not that it increases its secretion [XREF_BIBR]."
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"Hydroxychloroquine also reduces pro inflammatory cytokines, notably TNF-alpha and IL-6, and decreases insulin resistance."
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"Hydroxychloroquine may be able to partially reduce the post-receptor increased insulin clearance, accelerating insulin stimulated glucose transport which leads to better management of the disease."
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