IndraLab

Statements


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"Impaired ADAM10-AXL axis triggers retinal angiogenesis."

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"We first verified the reliability of M2-like polarizing communication measurements through comparison of known M2-like differentiation communication pathways, including CSF1-CSF1R , ADAM10-AXL and ZP3-MERTK , to M1-/M2-like cells (Figure  xref ) xref , xref ."

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"Having established that ADAM10 regulates AXL levels, we next investigated whether dysregulated ADAM10-AXL axis is involved in triggering retinal angiogenesis."

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"In all, our data showed that the activation of ADAM10-AXL axis exhibited potent anti-angiogenic effects."

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"Furthermore, we identified the impaired ADAM10-AXL axis as a driver of retinal angiogenesis."