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USP15 activates Stomach Neoplasms. 17 / 17
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"In this study, IHC analyses showed that the high expression of USP15 was closely related to the depth of invasion, LNI, TNM stage, which indicated that USP15 acted as an oncogene, thereby promoting GC invasion, metastasis, and progression."
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"Subsequently, we further found that USP15 can significantly promote the migration and invasion of GC cells in vitro."
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"Knockdown of USP15 inhibits cell proliferation, invasion, and EMT progression of GC in vitro."
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"The above findings indicated that USP15 may promote cell proliferation, migration, invasion and EMT process to become an oncogene of GC."
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"As shown in Figure 2D and Figure 2E, USP15 silencing suppressed GC cell migration and invasion."
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition (EMT) of GC in vitro, while overexpression of USP15 promoted these processes."
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"USP15 promotes cell proliferation, invasion and EMT progression of GC via regulating the Wnt/beta-catenin pathway, which suggests that USP15 is a novel potential therapeutic target for GC."
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"Collectively, these data demonstrated that USP15 overexpression promoted GC proliferation, invasion, and EMT progression."
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"USP15 promoted cell proliferation, invasion, and epithelial-mesenchymal transition of GC cells in vitro and tumor growth in vivo."
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition of GC in vitro, while overexpression of USP15 promoted these processes."
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"To confirm the role of the Wnt/β-catenin signaling pathway in the malignant biological behavior in GC mediated by USP15, western blotting was performed to investigate expression of β-catenin and Wnt/β-catenin downstream genes (including c-myc and cyclin D1)."
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"In contrast, USP15 knockdown attenuated the activity of Wnt/β-catenin signaling and inhibited GC progression both in vitro and in vivo, but the mechanism through which USP15 regulates this pathway remains unclear [41]."
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"USP15 promoted cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) of GC cells in vitro and tumor growth in vivo."
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"USP15 overexpression promotes cell proliferation, invasion, and EMT progression in GC."
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"Overexpression of USP15 promoted GC cell migration and invasion, while USP15-C269S did not (Figure 3D and E)."
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"Furthermore, USP15 promoted cell proliferation, invasion, and EMT progression via the Wnt/β-catenin signaling pathway in vitro and promoted the growth of GC cells in vivo."
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"USP15 promotes cell proliferation, invasion, and EMT progression of GC via regulating the Wnt/β-catenin pathway."
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