IndraLab

Statements

USP30 inhibits autophagy. 4 / 4
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"The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria."
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"USP30 can remove ubiquitin tags and participate in the regulation of mitochondrial morphology in cells, thus inhibiting mitochondrial autophagy [42]."
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"However, USP30 can also antagonize Parkin in the autophagy pathway ."
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"In mutant parkin cell lines, USP30 knockdown enhanced autophagy receptor sequestosome 1 (SQSTM1) levels, and its recruitment to damaged mitochondria rescued mitophagy deficiency."
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