IndraLab

Statements

USP4 activates TGFBR1. 4 / 4
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"As we have discussed above, USP4 can target the TGF-beta type I receptor and promote invasion and metastasis of breast cancer and high USP15 expression correlated with enhanced pSmad2 expression in ti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In particular, USP4 pre-activates and/or persistently increases TbetaRI stabilization."
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"Published studies revealed that , unlike USP15 , USP4 directly binds , stabilizes , and activates TbetaRI in the plasma membrane rather than via SMAD7-mediated recruitment to the active receptor as USP15 does ."
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"Therefore, USP4 mediates TbetaRI regulation via PI3K and Akt pathway, which is a strong modulator of TGF-beta pathway and plays a critical role in the crosstalk between TGF-beta and AKT signaling."
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