IndraLab

Statements

APP inhibits NLRP3. 3 / 3
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"In the Amyloid precursor protein (APP)/presenilin-1 (PS1) mouse model, U50488H (κ-opioid receptor agonist) ameliorated synaptic plasticity and AD-related symptoms by inhibiting NLRP3-induced hippocampal microglia pyroptosis (Song et al., 2021)."
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"Cho et al [XREF_BIBR] showed that autophagy contributes to the clearance of extracellular beta-amyloid (Abeta) fibrils and suppression of Abeta induced NLRP3 inflammasome."
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"Puerarin inhibits amyloid beta induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS dependent oxidative and endoplasmic reticulum stresses."
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