IndraLab

Statements

APP inhibits NLRP3. 12 / 12
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"Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Abeta."
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"Minocycline can decrease the levels of microglial activation and Aβ accumulation, probably via suppressing the NLRP3 inflammasome [146]."
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"In the Amyloid precursor protein (APP)/presenilin-1 (PS1) mouse model, U50488H (κ-opioid receptor agonist) ameliorated synaptic plasticity and AD-related symptoms by inhibiting NLRP3-induced hippocampal microglia pyroptosis (Song et al., 2021)."
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"In the APP/PS1 mice model of alzheimer's disease, Klotho upregulation boosts amyloid clearance and cognition by inhibiting NLRP3, encouraging microglia transformation, and managing the expression of the Aβ transporter, ultimately improving Aβ clearance in the brain [180]."
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"Cross-linked deposition of Aβ and Tau proteins in the brain can disrupt the normal regulation of NLRP3 inflammasome, leading to their abnormal expression, which then causes CNS chronic inflammation an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Also, Aβ, being one of the damage-associated molecular patterns (DAMP) known to activate NLRP3 inflammasome, we checked if the dwindling load of Aβ after treatment with IBC could reduce the activation of NLRP3 inflammasome."
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"It was reported that baicalin alleviated the pyroptosis and inflammatory injury of ARPE-19 cells induced by Aβ through the negative crosstalk of miR-223/NLRP3 in inflammatory signaling, suggesting that baicalin may be a potential candidate for the treatment of age-related macular degeneration [13]."
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"Cornuside alleviates cognitive impairments induced by Abeta 1-42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy."
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"Cho et al [XREF_BIBR] showed that autophagy contributes to the clearance of extracellular beta-amyloid (Abeta) fibrils and suppression of Abeta induced NLRP3 inflammasome."
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"Furthermore, TSG delivery in APP/PS1 Tg mice decreased indicators associated with ferroptosis, such as elevated lipid peroxidation and increased neuroinflammation, including NLRP3 [27]."
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"Correction: Cornuside alleviates cognitive impairments induced by Abeta 1-42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy."
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"Furthermore, inhibition of Aβ‐induced activation of the NLRP3 inflammasome was found to result in reductions in amyloid plaque in vivo, suggesting a positive feedback relationship between microglial inflammasome activation and Aβ pathology."
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