IndraLab

Statements

TNF increases the amount of TRPV1. 24 / 25
| 24
reach
"TNF-alpha increases expression of TRPV1 and TRPV4 mRNA, protein and immunostaining in synoviocytes after 8 hr."
19695100
reach
"Furthermore, vincristine administration induced the upregulation of tumor necrosis factor (TNF)-α production in DRGs, and inhibition of TNF-α synthesis with thalidomide in vivo reversed TRPV1 protein expression, as well as pain hypersensitivity induced by vincristine in rats."
29552137
reach
"TNF and IL-6 elevate gene expression or membrane expression of TRPV1 ."
30874629
reach
"In the present study, we investigated in cultured dorsal root ganglion (DRG) neurones, the somata of primary afferent fibres, whether TNFalpha increases TRPV1 receptor expression."
17851089
reach
"Long-term exposure of TNFα was shown to enhance TRPV1R-mediated currents in DRG neurons through the production of PGE2 (Nicol et al. 1997) and to upregulate TRPV1 expression through ERK activation (Hensellek et al. 2007)."
23918214
reach
"Furthermore, vincristine administration induced the upregulation of tumor necrosis factor (TNF)-alpha production in DRGs, and inhibition of TNF-alpha synthesis with thalidomide in vivo reversed TRPV1 protein expression, as well as pain hypersensitivity induced by vincristine in rats."
29552137
reach
"In addition, TNF-α was also able to produce subsequent upregulation of TRPV1 protein expression when applied to cultured DRG neurons employing a pathway involving extracellular-signal-related kinase rather than p38 signaling."
19655114
reach
"It is highly likely that TNF-α increases expression of TRPV1 and TRPV4 by mediating the up-regulation directly and/or through initiation of downstream events since the inhibitor reduced the immunostaining increase."
19695100
reach
"Obviously, TNF-α not only promotes TRPV1 expression at a translational level, but may also induce the directed TRPV1 trafficking to the surface membrane in DRGs in vincristine-treated rats."
29552137
reach
"TNF-alpha increases TRPV1 (8 hr peak) and TRPV4 (12 hr peak) immunostaining, mRNA and protein expression, with a TRPV1 shift to membrane fractions."
19695100
reach
"TNF is known to increase the expression level of TRPV1 by activating TRPV1-dependent ERK signaling, but the influence of this overexpression on the effect of RTX is still unclear [40]."
28831207
reach
"It has been shown previously that TRPV1 receptor expression and sensitivity to capsaicin may be modulated by TNFα pretreatment [4,29-31]."
20796308
reach
"Expression of TRPV1 in synovial fibroblasts from patients with rheumatoid arthritis and OA14 and in the synoviocyte cell line SW98220 has been shown to be upregulated by TNFα."
21616913
reach
"Furthermore, we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the TNFalpha induced increase of TRPV1 receptor expression."
17851089
reach
"It should be noted that inhibition of TNF-α has been reported to decrease expression of TRPV1 and/or TRPA1 and attenuate the effects of these receptors’ activation in sensory nerves in the processing of inflammatory responses (Hu et al., 2010; El Karim et al., 2015; Meng et al., 2016)."
30374312
reach
"In summary, our data demonstrate that TNFalpha directly enhances the sensitivity of rat trigeminal neurons to capsaicin via both rapid, non-genomic mechanisms as well as sustained genomic regulation in TRPV1 expression."
18582539
reach
"This long-term up-regulation of TRPV1 expression by TNFalpha correlated with enhancement in capsaicin-induced calcitonin gene-related peptide release (P<0.05)."
18582539
reach
"As an example, TNF-α activates the TNF-α receptor 1 (TNFR1) to promote Na 1.9 phosphorylation, while IL-6, by activating the gp130 channel, increases the expression of TRPV1 and TRPA1 (reviewed in [41])."
33183347
reach
"Although there are reports that TNF-alpha increases TRPV1 expression through TNF-alpha receptors and TRPV1 induced activity is enhanced by TNF-alpha administration [XREF_BIBR - XREF_BIBR], it would be interesting to know if they can reciprocally regulate one another."
19531269
reach
"The expressions of TRPA1, TRPV1 and IL-31 mRNA in HaCaT cells were increased by TNF-α treatment and partially decreased by luteolin 7-methyl ether (4) treatment."
| PMC
reach
"In a model of cancer-related pain, TNFα acted via TNFR2 to increase TRPV1 expression resulting in thermal hyperalgesia [39]."
27793571
reach
"Furthermore, TNF-α increases expression of TRPV1 in DRG via TNFR1 receptor with a requirement for ERK signaling [11]."
21958434
reach
"This cytokine increases TRPV1 expression on dorsal root ganglion and trigeminal ganglion neurons via the extracellular signal-regulated kinase pathway.96,97 Additionally, tumor necrosis factor alpha rapidly sensitizes TRPV1 activity and enhances the Ca influx induced by capsaicin."
22096371
reach
"In addition, TNF increases the TRPV1 protein level and number of TRPV1-expressing neurons."
28831207