IndraLab

Statements

USP12 activates cell population proliferation. 11 / 11
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"It has been mentioned previously that USP12 silencing inhibits PC cell proliferation, induces cell cycle arrest, and promotes apoptosis [42]."
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"Therefore, it can be inferred that USP12 can promote the proliferation of PCa cells."
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"Depletion of USP12 decreased PC cell proliferation, increased apoptosis and caused G 1 arrest ( Burska et al., 2013 and McClurg et al., 2014 )."
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"In vitro experiments in HCC cell lines showed that USP12 knockdown inhibited cell proliferation through G2/M arrest."
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"Knockdown of USP12 inhibited HCC cell proliferation and promoted apoptosis via the p38-MAPK pathway."
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"On the other hand, USP12 promoted prostate cancer (PC) cells proliferation by forming a complex with Uaf-1 and WDR20 and deubiquitinating AR, thereby increasing AR stability and transcriptional activity, whereas USP12 silencing led to a significant decrease in PC cell proliferation [42, 64]."
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"Furthermore, Usp12 silencing was shown to reduce proliferation of PC cells."
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"CCK8 assays showed that deletion of USP12 inhibited gastric cancer cell proliferation (Fig. 2B, C)."
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"Previous studies show that USP12 promotes the growth of multiple myeloma (MM) cells and USP12 knockdown significantly inhibits cell proliferation."
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"By the CCK8 assay, it was observed that the proliferation of gastric cancer cells was suppressed by USP12 deletion, and this inhibition was partially mitigated by YAP overexpression (Fig. 5D)."
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"In addition, USP12 activates CD4 + T cell proliferation by stabilizing BCL10 and targeting the NF-κB signaling pathway."
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