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TP53 activates ATXN3. 2 / 2
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"Our data described in the present manuscript establish a mechanistic link between mutant ATXN3 expression and aberrant p53 pathway activation in SCA3, as previously reported [XREF_BIBR, XREF_BIBR]."
25590633
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"We report that persistent accumulation of DNA damage and strand breaks and chronic activation of the serine/threonine kinase ATM and the downstream p53 and protein kinase C-delta pro apoptotic pathways trigger neuronal dysfunction and eventually neuronal death in SCA3."
25590633