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Mice activates USP22. 2 / 2
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"Consistent with these results, no increase in ERBB2, phospho-ERBB2, or ERα protein levels were observed in endpoint tumor lysates isolated from USP22 overexpressing mice, relative to tumor lysates isolated from MMTV-NIC mice (Fig 2A top)."
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"We observed over branching of the mammary glands in USP22 overexpressing mice, along with aberrant up regulation of many of the same signaling pathways that were down regulated in Usp22 null embryos, including estrogen receptor, extracellular signal-regulated kinase /Mitogen-activated protein kinase (ERK/MAPK), and TGFβ signaling [16, 17]."
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