IndraLab

Statements

PRPF8 activates CCP110. 4 / 4
| 4
reach
"PRPF8 promotes CP110 removal to initiate ciliogenesis by binding to the linear ubiquitin chains."
34813648
reach
"Subsequently, PRPF8 at the distal end of the mother centriole interacts with the linear ubiquitin chains of CP110 and promotes the removal of CP110 from the mother centriole, thus initiating ciliogenesis (Fig. 7 G)."
34813648
reach
"At the beginning of ciliogenesis, PRPF8 serves as the receptor for linear ubiquitin chains of CP110 and disappears from the mother centriole to promote CP110 removal."
34813648
reach
"Strikingly, depletion of PRPF8 in RPE-1 cells dramatically suppressed CP110 removal from the mother centrioles after serum starvation and significantly inhibited ciliogenesis (Fig. 5, C–E; and Fig. S5 C)."
34813648