IndraLab

Statements

USP8 increases the amount of CCND1. 3 / 3
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"Furthermore, knockdown of USP8 reduced the protein-level expression of CyclinD1, CDK4, and CDK6 ( Fig. 3 E)."
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"We then evaluated the expression of β-catenin target genes (CCND1, c-MYC and LGR5) and observed that knockdown of USP8 inhibited the transcription of CCND1, c-MYC and LGR5 (Fig. 1G, H)."
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"Furthermore, the overexpression of USP8 markedly enhanced the protein expression of CyclinD1, CDK4, and CDK6 ( Fig. 2 E)."
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