IndraLab

Statements

USP25 activates BRCA2. 7 / 7
| 7
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"We next asked whether USP21 mediated BRCA2 stabilization involves USP21 interaction with the BRCA2 and RAD51 complex."
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"USP21-mediated BRCA2 stabilization promotes RAD51 loading at DSB sites."
| PMC
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"USP21 stabilizes BRCA2 in patient derived HCC tumor cell lines, protects from DNA damage and promotes tumor cell growth in a BRCA2 dependent manner."
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"We next asked if USP21 mediated BRCA2 fragment stabilization is associated with changes in poly-ubiquitination."
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"Our data collectively point to a mechanism of USP21 mediated BRCA2 stabilization via proteasomal degradation."
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"To gain mechanistic insight into USP21 function in HCC, we asked whether USP21 can modulate BRCA2 stability in HCC derived tumor cells 50."
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"Together, these findings support the notion that USP21 promotes BRCA2 stability and protects from DNA damage accumulation in BRCA2-proficient tumor cells, which can in turn contribute to increased tumor growth and, ultimately, a more malignant phenotype."
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