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Tamoxifen inhibits MAP3K7. 11 / 11
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"Rapid weight loss, diarrhea, and death were observed within 5 days after tamoxifen-induced TAK1 deletion (Fig. 1k, l)."
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"Thus, the activation of RIPK1 kinase plays an important role in dysregulated innate immune response to promote ileitis and early-stage colitis in adult Tak1 mice.Tak1 Ripk1 mice began to lose weight 5 days after tamoxifen-induced TAK1 deletion (Fig. 1l)."
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"Similar to these findings, Sassmann-Schweda et al have recently reported that tamoxifen inducible inactivation of TAK1 causes adipocyte cell death through apoptosis [XREF_BIBR]."
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"Map3k7 (f/f) Cre-ER (TM) mice (in which tamoxifen induces global TAK1 deletion) and control Map3k7 (f/f) mice were given tamoxifen at the time of unilateral ureteric obstruction (UUO) and then killed 2, 4, or 5 days later."
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"Tak1 Fadd Mlkl mice, but not Tak1 Mlkl or Tak1 Fadd Mlkl mice, survived to 21 dpi when the mice were sacrificed, with normal weight after TAK1 deletion induced by tamoxifen injection (Fig. 2i, j)."
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"Tamoxifen-dependent conditional depletion of TAK1 in microglial cells was induced in Cx3cr1 creER -Tak1 fl/fl mice."
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"Importantly, tamoxifen-inducible inactivation of TAK1 in post-natal mice led to severe muscle wasting and development of kyphosis."
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"Tak1 gene deletion was induced by 5 consecutive day treatment of 0.5-1 mg/mouse/day tamoxifen."
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"In ER-TAK1 fl/fl mice, tamoxifen application on local skin could induce TAK1 deletion in various cell types including stromal cells, particularly cutaneous DC that are considered to play a central role for initiating response to haptens."
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"Although the role of TRAF6 in the survival of adipocytes has not been documented, a recent study has shown that tamoxifen inducible inactivation of TAK1 promotes apoptosis in adipocytes [XREF_BIBR]."
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"These results suggest that TRADD and RIPK1 kinase are both important for driving colitis in adult TAK1 IEC-deficient mice.Notably, TRADD-IEC knockout alone was not sufficient to protect the loss of body weight and lethality in adult Tak1 mice after tamoxifen-induced TAK1 deletion (Supplementary Fig. 6d, e)."
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