IndraLab

Statements


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"In conclusion, our results indicate that NF-κBp65 is involved in the regulation of USP15 in MM proliferation and apoptosis and that USP15 inhibits MM apoptosis through activating a feedback loop with NF-κBp65."

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"These results suggest that targeting USP15 may both induce tumor cell apoptosis and boost antitumor T cell responses and, thus, have important clinical applications."

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"These findings suggest that targeting USP15 may both induce tumor cell apoptosis and boost antitumor T cell responses."

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"PDTC treatment inhibits USP15 overexpression induced MM cell proliferation and apoptosis inhibition."

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"Zhou et al. noted that depletion of USP15 in multiple myeloma enhanced the NFkappaB transcriptional activity and reduced the rate of apoptosis."

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"USP15 inhibited MM cell apoptosis through activating a feedback loop with NF-kappaBp65."

sparser
"USP15 inhibited MM cell apoptosis through activating a feedback loop with NF-κBp65."

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"USP15 overexpression inhibits MM cell apoptosis."

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"Overexpression of USP15 promoted proliferation and inhibited apoptosis, and these effects were inhibited by PDTC treatment."

eidos
"Overexpression of Ubiquitin-Specific Protease15 ( USP15 ) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma ."

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"USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-kappaBp65."

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"It has been reported that the reduced RBM5 and USP15 expressions result in tumor cell proliferation [XREF_BIBR, XREF_BIBR] and induce tumor cell apoptosis [XREF_BIBR], respectively."

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"It has been recently demonstrated that inhibition of USP15 both induced tumor cell apoptosis and boosted antitumor T cell responses, and thus have important clinical applications XREF_BIBR."

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"Together, these findings suggest that USP15 inhibition may not only promote cancer cell apoptosis but also boost T cell mediated anti-tumor immunity."

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"Our results suggest that inhibition of USP15 may both induce tumor cell apoptosis and boost antitumor T cell responses."

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"In conclusion, our results indicate that NF-kappaBp65 is involved in the regulation of USP15 in MM proliferation and apoptosis and that USP15 inhibits MM apoptosis through activating a feedback loop with NF-kappaBp65."