IndraLab

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USP15 inhibits apoptotic process. 18 / 19
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"USP15 inhibited MM cell apoptosis through activating a feedback loop with NF-kappaBp65."
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"In conclusion, our results indicate that NF-κBp65 is involved in the regulation of USP15 in MM proliferation and apoptosis and that USP15 inhibits MM apoptosis through activating a feedback loop with NF-κBp65."
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"USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-kappaBp65."
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"In conclusion, our results indicate that NF-kappaBp65 is involved in the regulation of USP15 in MM proliferation and apoptosis and that USP15 inhibits MM apoptosis through activating a feedback loop with NF-kappaBp65."
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"These findings suggest that targeting USP15 may both induce tumor cell apoptosis and boost antitumor T cell responses."
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"PDTC treatment inhibits USP15 overexpression induced MM cell proliferation and apoptosis inhibition."
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"It has been recently demonstrated that inhibition of USP15 both induced tumor cell apoptosis and boosted antitumor T cell responses, and thus have important clinical applications XREF_BIBR."
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"Zhou et al. noted that depletion of USP15 in multiple myeloma enhanced the NFkappaB transcriptional activity and reduced the rate of apoptosis."
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"USP15 inhibited MM cell apoptosis through activating a feedback loop with NF-κBp65."
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"Overexpression of USP15 promoted proliferation and inhibited apoptosis, and these effects were inhibited by PDTC treatment."
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"Thus, inhibiting USP15 may both induce cancer cell apoptosis and boost antitumor T cell response, which has important clinical applications for cancer therapy [99] ."
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"Our results suggest that inhibition of USP15 may both induce tumor cell apoptosis and boost antitumor T cell responses."
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"These results suggest that targeting USP15 may both induce tumor cell apoptosis and boost antitumor T cell responses and, thus, have important clinical applications."
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"USP15 has been shown to repress apoptosis in melanoma and colorectal cancer cell lines through stabilizing the E3 ubiquitin protein ligase MDM2 [16]."
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"It has been reported that the reduced RBM5 and USP15 expressions result in tumor cell proliferation [XREF_BIBR, XREF_BIBR] and induce tumor cell apoptosis [XREF_BIBR], respectively."
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"USP15 overexpression inhibits MM cell apoptosis."
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"Recent studies have demonstrated that inhibiting USP15 prevents glutamate-induced oxidative stress and neuronal apoptosis by activating the NRF2/heme oxygenase 1 (HO-1) signaling pathway in HT22 cells [141]."
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"Together, these findings suggest that USP15 inhibition may not only promote cancer cell apoptosis but also boost T cell mediated anti-tumor immunity."
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