IndraLab

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"T As a consequence, we delved further into whether AG could inhibit inflammasome activation by measuring key components of the NLRP3 inflammasome, encompassing the NOD-like receptor NLRP3, the adaptor protein ASC, and caspase-1."

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"Overall, AG could attenuate neuroinflammation and improve SBI through hindering the NF-κB signaling pathway and NLRP3 inflammasome activation.In addition, we collated the literature on AG in the treatment and prevention of ASCVD (Table 1)."

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"We also conducted a series of quantitative studies to demonstrate that AGN prevents HIF-1alpha accumulation and NLRP3 inflammasome activation, thereby alleviating KOA synovitis and fibrosis."

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"The reseach also reported AG inhibited NLR family pyrin domain containing 3 (NLRP3) inflammasome and its downstream targets, such as casp-1 (p20) and IL-1β(Ahmed et al., 2021; Lo et al., 2021)."