IndraLab

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Hm1a activates SCN1A. 3 / 3
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"This selective activation of Nav1.1 by Hm1a restores the function of inhibitory interneurons without affecting the firing of excitatory neurons [106,107]."
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"7 The Petrou group showed that application of Hm1a to mouse brain slices rescued hippocampal CA1 PV+ fast spiking interneuron function in Scn1a +/- DS mice but, surprisingly, had no effect on CA1 inhibitory neuron firing in WT littermate mice or on excitatory CA1 pyramidal neurons in DS mice."
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"Hm1a-mediated activation of Nav1.1 is able to restore the function of inhibitory interneurons from Dravet syndrome mice without affecting the activity of excitatory neurons, and intracerebroventricular infusion of Hm1a in the Dravet syndrome rodent model rescued the animals from seizures and premature death [105]."
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