IndraLab

Statements

Simvastatin inhibits CTSB. 9 / 9
| 9
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"By contrast, E64 and pepstatin A, which are known inhibitors of cathepsin B and cathepsin D, markedly inhibited the activities of cathepsin B and cathepsin D."
27780924
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"Since cathepsin B and D are functionally related [XREF_BIBR - XREF_BIBR], THP-1 cells were pre-incubated with combined CA-074Me and pepstatin A (50muM or 100muM of each) for one hour to inhibit cathepsin B and D simultaneously or with 5muM of z-LLY-fmk to inhibit cathepsin L, and then stimulated with 50ng/mL IL-32gamma and infected with MTB H37Rv [XREF_BIBR - XREF_BIBR]."
25887904
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"Treatment with E-64 or CA074Me (2 specific inhibitors of cathepsin B) or with pepstatin A (a specific inhibitor of cathepsin D) was cytotoxic for 2 neuroblastoma cell lines having different degrees of malignancy."
11857353
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"Both CA-074 (a specific inhibitor of cathepsin B) and pepstatin A (a specific inhibitor of cathepsin D) showed an inhibitory effect on the IL-2 production from an OVA specific, I-Ad- restricted helper[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7721331
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"Both CA-074 (a specific inhibitor of cathepsin B) and pepstatin A (a specific inhibitor of cathepsin D) showed an inhibitory effect on the IL-2 production from an OVA specific, I-Ad-restricted helper T (Th) cell clone upon stimulation with OVA presented by the I-Ad-positive APC."
7721331
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"There was also a tendency of reduced cathepsin B activity caused by increasing simvastatin concentration (data not shown)."
24416446
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"A plausible expla- nation is that pepstatin A inhibits an esterolytic activity of cathepsin B or of a contaminating esterase."
8341280
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"The neutral proteinase and cathepsin B like activity were inhibited by leupeptin and not by pepstatin while the converse obtained for cathepsin D activity."
2425054
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"Simvastatin decreases the activity of cathepsin B and cathepsin A and pravastatin increases the activity of cathepsin B."
| PMC