IndraLab

Statements

ADAM10 activates TLR4. 2 / 2
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"IL-1ra, an anti-TLR4 antibody, and also the inhibition of JNK and NF-κB restored the decrease in synaptic functions in Tir8/Sigirr-deficient mice, demonstrating the key role of IL-1RI-and TLR4-activation by IL-1α and high mobility group box 1 (HMGB1), respectively, in this model."
23112799
sparser
"IL-1α and high mobility group box 1 (HMGB1), which activate IL-1R1 and TLR4, respectively, were proposed to play a central role in the phenotype observed and the expression levels of both molecules were increased in IL-1R8-deficient mice."
27148268