IndraLab

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ADAM10 activates TLR4. 9 / 9
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"However, the unchanged protein and mRNA expression of ADAM10 in TLR4 ( Tlr4 ) silencing cancer cells alone, suggesting the direct platelet-tumor cell interaction triggered or enhanced TLR4/ADAM10 sign[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38280480
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"In the present study, the increase in cytosolic Ca 2+ led to a marked increase in ADAM10 on the cell surface, while inhibition or depletion of ADAM10 prevented EGCG-induced ectodomain shedding of TLR4[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31557474
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"Hence, it's plausible that liraglutide reduces the inflammatory responses to LPS and TNF-α by causing ADAM10-mediated ectodomain shedding of TLR4 and TNFR1, though this needs to be confirmed with appr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35041837
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"The effective concentrations of EGCG observed in the present study might be higher than the plasma level readily achievable with oral administration.In summary, EGCG effectively attenuated the effects[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31557474
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"IL-1α and high mobility group box 1 (HMGB1), which activate IL-1R1 and TLR4, respectively, were proposed to play a central role in the phenotype observed and the expression levels of both molecules were increased in IL-1R8-deficient mice."
27148268
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"Together, these data might suggest that acute aerobic exercise at 80% of V̇o is not sufficient to adequately activate ADAM10 to promote cleavage of RAGE or TLR4 protein or accretion of circulating sRAGE isoforms in this relatively healthy cohort lacking an overt inflammatory phenotype.Previous work by our laboratory demonstrated circulating esRAGE as the strongest sRAGE isoform correlated with BMI (42) and most responsive to weight loss (62)."
37675469
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"As shown in Fig. 7 A and B, both GI254023X and depletion of ADAM10 inhibited EGCG-induced ectodomain shedding of TLR4."
31557474
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"IL-1ra, an anti-TLR4 antibody, and also the inhibition of JNK and NF-κB restored the decrease in synaptic functions in Tir8/Sigirr-deficient mice, demonstrating the key role of IL-1RI-and TLR4-activation by IL-1α and high mobility group box 1 (HMGB1), respectively, in this model."
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"A recent study characterized protein secretion from human macrophages after activation of caspase-4/5 by intracellular LPS and found secretion of the metalloproteases a disintegrin and metalloproteina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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