IndraLab

Statements

USP37 activates BRCA1. 4 / 4
| 4
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254
reach
"In relation to its role maintaining chromosomal integrity, USP37 localizes to double-strand breaks and promotes BRCA1 inclusion into complexes responsible for homologous recombination 16."
30858488
reach
"On the other hand, we also found that USP26 and USP37 promote the efficient association of BRCA1 with PALB2."
26101254
reach
"Loss of USP26 or USP37 impairs HR by counteracting RAP80 dependent sequestration of BRCA1."
26101254