IndraLab

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BAP1 activates IRF8. 3 / 3
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"We also examined whether ASXL1-MT and BAP1 upregulated posterior HOXA genes and IRF8 in human RUNX1-ETO cells by qRT-PCR."
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"ASXL1-MT and BAP1 induces upregulation of HOXA genes and IRF8."
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"In addition to posterior Hoxa genes, we found that coexpression of ASXL1-MT and BAP1 in c-Kit + cells led to upregulation of Irf8, a master regulator of monocyte differentiation, at both mRNA and protein levels 37."
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