IndraLab

Statements

BAP1 activates IRF8. 7 / 7
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"ASXL1-MT and BAP1 induces upregulation of HOXA genes and IRF8."
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"In addition to posterior Hoxa genes, we found that coexpression of ASXL1-MT and BAP1 in c-Kit + cells led to upregulation of Irf8, a master regulator of monocyte differentiation, at both mRNA and protein levels 37."
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"Moreover, the mutant ASXL1 (ASXL1-MT)/BAP1 complex promotes MLL rearrangement leukemia progression by reducing the upregulation of HOXA5, HOXA7, HOXA9, and IRF8 induced by H2AK119ub1 [136]."
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"RNA sequencing analyses revealed that reduced BAP1 expression suppressed ASXL1 Y591X -induced upregulation of the transcription factors activator protein 1 ( AP-1 ) and early growth response 1/2 ( EGR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We also examined whether ASXL1-MT and BAP1 upregulated posterior HOXA genes and IRF8 in human RUNX1-ETO cells by qRT-PCR."
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"Additionally, BAP1-inactivation notably increases IRF8 activity, which is involved in DC differentiation."
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"Further chromatin immunoprecipitation quantitative PCR (ChIP-qPCR) assays confirmed that BAP1 reduction rescued the decreased occupancy of H2AK119Ub around the transcription start site (TSS) region of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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