IndraLab

Statements

Dinitrogen inhibits KCNH2. 3 / 3
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"It was reported that basic nitrogen in lipophilic molecules can increase hERG inhibition through cation accumulation [ 85 ]."
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"Introduction of nitrogen in the terminal aromatic ring decreased hERG activity considerably ( 5g – i )."
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"XREF_BIBR, XREF_BIBR In pharmacophore models for hERG blockade, it is reported that a basic nitrogen in lipophilic molecules can increase hERG inhibitory potency via pi cation stacking."
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