
IndraLab
Statements
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reach
"USP22 depletion enhanced Sirt1 degradation and displayed combined effects with AGEs to further promote FN and TGF-beta1 expression."
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sparser
"Moreover, we found that USP22 inhibited the SIRT1 gene to regulate ferroptosis-induced cardiomyocyte death."
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reach
"Additionally, SIRT1 instability caused by loss of USP22, a deubiquitinating enzyme that stabilizes SIRT1, is associated with the defective embryogenesis in USP22 null mice [XREF_BIBR]."
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eidos
"USP22 Inhibits SIRT1 to Regulate Ferroptosis-Induced Cardiomyocyte Death A previous study has shown that USP22 possesses the ability to stabilize SIRT1 by the process of deubiquitination ( Lin et al ., 2012 ) ."