IndraLab

Statements

USP22 inhibits SIRT1. 11 / 15
| 1 8 2
reach
"The USP22 inhibition‐induced decrease in SIRT1 expression was partially reversed by treatment with the proteasome inhibitor MG132, but not the autophagy inhibitor chloroquine (Figure 5G), suggesting that USP22 may inhibit the degradation of SIRT1 through a proteasome‐dependent pathway."
39135915
reach
"USP22 depletion enhanced Sirt1 degradation and displayed combined effects with AGEs to further promote FN and TGF-beta1 expression."
25375034
reach
"USP22 inhibits activation of apoptotic pathways by stabilizing SIRT1."
35935969
reach
"USP22 inhibits p53 activity and transcriptional activation of the p53 target gene by stabilizing SIRT1 through deubiquitination to suppress cell apoptosis [ 29 ]."
33989708
sparser
"Moreover, we found that USP22 inhibited the SIRT1 gene to regulate ferroptosis-induced cardiomyocyte death."
33192549
eidos
"USP22 Inhibits SIRT1 to Regulate Ferroptosis-Induced Cardiomyocyte Death A previous study has shown that USP22 possesses the ability to stabilize SIRT1 by the process of deubiquitination ( Lin et al ., 2012 ) ."
33192549
reach
"Furthermore, USP22 reduces hepatic steatosis and obesity by stabilizing Sirt1 protein and regulating Sirt1-dependent mitochondrial respiration (145).3 Discussion."
38322269
reach
"This study demonstrated that teneligliptin acts as a negative regulator of PRDX3 acetylation through USP22-mediated SIRT1 activation [12]."
39828973
reach
"Additionally, SIRT1 instability caused by loss of USP22, a deubiquitinating enzyme that stabilizes SIRT1, is associated with the defective embryogenesis in USP22 null mice [XREF_BIBR]."
30630664
sparser
"USP22 Inhibits SIRT1 to Regulate Ferroptosis-Induced Cardiomyocyte Death."
33192549
reach
"For another USPs family member USP22, we found that the downregulated USP22 protein levels was accompanied by increased total ubiquitination levels in AGEs-treated GMCs, and USP22 activation can rever[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32442538