IndraLab

Statements

USP18 binds TRIM31. 8 / 8
1 | 7
sparser
"Therefore, we hypothesized that USP18 interacts with TRIM31 and subsequently enhances the interaction between TRIM31 and MAVS."
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sparser
"To test our hypothesis, we first examined whether the interaction between USP18 and TRIM31 existed."
34016972
sparser
"We observed that USP18 did interact with TRIM31 through the Co-IP assay (Fig.  xref )."
34016972
sparser
"Immunofluorescence assay showed that USP18 can colocalize with TRIM31 (Fig.  xref ), further suggesting the interaction between USP18 and TRIM31."
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sparser
"More importantly, we observed that the interaction between endogenous USP18 and TRIM31 was increased following SeV infection (Fig.  xref ), indicating USP18 may control the activity of TRIM31."
34016972
biogrid
No evidence text available
34016972
sparser
"Moreover, USP18 interacts with TRIM31 to promote the K63-linked polyubiquitination of MAVS and then positively regulates innate antiviral immunity ( xref )."
36620540
sparser
"The fact that different domains of MAVS mediate its interaction with TRIM31 and USP18 further suggests that USP18 is very likely to promote the interaction between TRIM31 and MAVS."
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