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PSMD14 activates Neoplasm Metastasis. 25 / 25
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"These findings suggest that PSMD14 could obviously induce EMT process through stabilizing SNAIL.Since SNAIL is reported to be involved in tumorigenesis and metastasis through EMT process [ 6–9 ], we p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Through classification of HCC patients from independent cohorts, in silico screening of DUBs expression and functional analyses, we demonstrated that the dubiquitinase POH1 deubiqutinates and stabilizes the TGF-β receptors and thereby potentiates tumor metastasis."
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"PSMD14, OTUB1, USP26, and EIF3H, by stabilizing Snail, promote the occurrence of metastasis[24-27]."
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"Apparently, knockdown of PSMD14 suppressed SNAIL-induce EMT and tumor metastasis."
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"Taken together, in this study, PSMD14 is characterized as an oncogenic protein to enhance tumor metastasis by regulating SNAIL stability in esophageal squamous cell carcinoma.Several studies proved th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Gain- and loss-of-function experiments showed that silencing PSMD14 notably attenuated the growth, invasion, and metastasis of TNBC cells in vitro and in vivo."
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"This suggests that PSMD14 inhibition can suppress both growth and metastasis through SMAD3 induction and SLUG reduction ."
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"The expression of PSMD14 is significantly higher in hepatocellular carcinoma than in normal liver tissues, and the knockdown of PSMD14 expression inhibited hepatocellular cancer proliferation and metastasis by down-regulation of GRB2 (Lv et al., 2020)."
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"Additionally, PSMD14 can accelerate hepatocellular carcinoma development and metastasis by stabilizing GRB2 [22]."
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"The results showed that overexpression of POH1 significantly promoted metastasis of MHCC97L HCC cells in vivo (Fig. S5e)."
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"PSMD14 enhances hepatocellular carcinoma growth and metastasis [26]."
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"Furthermore, in vivo assays show that knockdown of PSMD14 inhibits the growth, lung and abdominal metastasis of ovarian cancer."
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"Finally, PSMD14 knockdown in PC arrested tumor growth and lung metastasis."
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"Furthermore, we observed that PSMD14 promoted proliferation, migration, and invasion in vitro and tumor growth metastasis in vivo by stabilizing GRB2 protein."
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"Given that POH1 regulates the stability of Smad3, we propose that POH1 affects Smad3-mediated cellular function and promotes cell invasion and tumor metastasis in NCSLC."
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"PSMD14 is known to enhance HCC progression and metastasis by stabilizing GRB2 [41]."
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"In these malignancies, PSMD14 contributes to tumor progression, metastasis, and resistance to chemotherapy and radiotherapy by modulating protein deubiquitination [[17], [18], [19], [20], [21]]."
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"PSMD14 knockdown inhibited human bladder cancer cell metastasis in vitro and in vivo."
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"This suggests that PSMD14 inhibition can suppress both growth and metastasis through SMAD3 induction and SLUG reduction."
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"The results of the animal experiments ( Fig. 6 L) revealed that POH1 promotes liver metastasis; therefore, we examined the protein levels of POH1 and Smad3 in metastatic liver tissue originating from [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Based on these findings, we suspected that EMT-related transcription factor Snail1 could be crucial for PSMD14-induced metastasis via GRB2 and TGF-β signaling.Recently, specific, small-molecule inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistently, our findings demonstrate that POH1 promotes cell proliferation, invasion, and metastasis in NSCLS by mediating Smad3 stability."
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"Also, PSMD14 promoted HCC cell and tumor growth while inducing cell migration and tumor metastasis in in-vitro and in-vivo by stabilizing GRB2 via deubiquitylation ( Lv et al., 2020 )."
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"Moreover, abnormal overexpression of PSMD14 contributes to tumor growth and metastasis."
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"In addition, OTUB1 (an OTU family protein) and PSMD14 (a JAMM family protein) promotes metastasis of human esophageal squamous carcinoma by stabilizing Snail [21,22]."
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