IndraLab

Statements


OTUD7B inhibits UBE2S. 3 / 3
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"In response to DSBs, Cezanne antagonizes the activity of RNF8 and Ube2S in K11-linkage ubiquitin modification of chromatin-bound proteins, including H2A/H2AX, on damaged chromatin (Paul and Wang 2017)."

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"In response to DSB, Cezanne antagonizes the activity of RNF8 and UBE2S [146] ."

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"This is consistent with our previous finding that Cezanne antagonizes RNF8 and Ube2S-dependent K11-conjugation on damaged chromatin (Paul and Wang 2017)."