IndraLab

Statements

USP25 activates cell differentiation. 6 / 6
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"Knockdown of USP21 induces mouse ESC differentiation."
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"Reintroduction of USP21 efficiently rescued the mESC differentiation caused by USP21 depletion, but failed to rescue mESC differentiation caused by Nanog knockdown (XREF_FIG)."
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"Depletion of USP21 caused mESC differentiation."
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"The findings (Figure 2(B)) revealed that the absence of USP25 led to a higher prevalence of Th1 and Th17 cells in the spleen compared to wild-type mice, while there was no notable difference in the proportion of Th2 lymphocytes.To investigate the impact of USP25 on the differentiation of Th1, Th2, and Th17 cells in vitro, we isolated spleen lymphocytes from both wild-type and USP25−/− mice and prepared cell suspensions for the purpose of isolating CD4+ T lymphocytes and inducing their differentiation."
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"Depletion of USP21 promoted the differentiation of mESCs and reduced the efficiency of somatic cell reprogramming."
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"The results showed that Usp18 knockdown significantly increased the osteogenic potential of MSCs, whereas Usp21 deletion decreased the osteoblastic differentiation of MSCs (Fig. S1C–F)."
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