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OTUD5 deubiquitinates TRIM25. 2 / 3
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"In tumor cells, OTUD5 promotes tumor progression by deubiquitinating TRIM25 [9]."

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"Besides, OTUD5 regulates gene transcription and inhibits tumorigenesis by deubiquitinating TRIM25, providing forceful evidence for the synergistic effect of deubiquitinating enzyme and ubiquitin ligase [34]."