IndraLab

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USP10 inhibits PI3K. 3 / 3

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"USP10 suppresses ABCG2-induced malignant characteristics of doxorubicin-resistant thyroid cancer by inhibiting PI3K/AKT pathway."

37919637

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"While A20 inhibits PtdIns3P signaling by removing the TRAF6 dependent Lys63 linked chains from Beclin 1, the enzymes USP10 and USP13 prevent PI3K and III complex components from their degradation and, therefore, support autophagy."

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"Mechanistically, overexpressing USP10 inhibited PI3K/AKT pathway by activating PTEN."

37919637

INDRA sources:

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IndraLab

Statements

USP10 inhibits PI3K. 3 / 3

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