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TNF increases the amount of TNFAIP3. 34 / 39
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"TNF-α induced expression of TNFAIP3 and BIRC2 was also downregulated in PSMD10 knockdown clones."
35378311
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"Administration of TPT or SN-38, a biological active metabolite of irinotecan [ xref , xref ], strongly interfered with the TNFα-induced expression of IL8 , NFKBIA (NF-κB inhibitor α), TNFAIP3 (TNFα Induced Protein 3) and ICAM1 (intercellular adhesion molecule 1), while inhibition of CXCL2 and CXCL10 expression was less pronounced ( xref C)."
31242600
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"TNFα-induced A20 mRNA expression is not further induced by Dex."
29738549
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"In primary human airway smooth muscle cells, TNFAIP3 expression was induced by TNF."
28039105
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"To confirm our speculation, we pre-treated the BMDMs with TNFalpha, which could increase the levels of endogenous A20 and TNFAIP3."
32843955
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"Strikingly, Gerber’s lab has recently shown that the transcriptional cooperation between GR and NF-κB constitutes the main mechanism explaining the augmentation of TNF-induced A20 expression by dexamethasone (i.e., TNFAIP3, TNF alpha induced protein 3) in airway epithelial and smooth muscle cells ( xref ; xref )."
32473159
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"Because LPS and TNFα induced A20 transcription in macrophages is regulated by Nrf2, we propose that excessive inflammation suppression by Nrf2 is multi-faceted and occurs, at least in part, via A20 dependent termination of NF-κB and MAP kinase signaling."
34073293
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"TNFalpha increased the expression of IL6, ICAM1, and TNFAIP3 in both cell lines (XREF_FIG)."
24141032
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"We found that Nrf2 does not regulate TNFα-induced A20 expression in LDMΦs but regulates expression of other genes such as Tnfaip1 and Tnfaip2 ."
34073293
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"Also, the combination of Dex and CpdA does not differentially affect the TNFα-induced expression of A20 and NFKBIA compared to Dex treatment ( xref , xref )."
29738549
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"Together, these data suggest that TNFα signaling via TNFR2 promotes the expression of the anti-inflammatory mediator TNFAIP3/A20, which seems to prevent IL-17A expression in regulatory T cells, as ablation of TNFα signaling suppresses TNFAIP3/A20 and results in increased IL-17A expression in human Treg."
32038615
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"TNF induces TNFAIP3 expression in all tissues including mouse and human intestinal epithelial cells XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
22031828
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"Notably, we observed a significant upregulation of TNFalpha-induced protein 3 (TNFAIP3) expression with increasing concentrations of TBMS1."
40098908
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"Additionally, GFPT2 expression was not required for TNF induced BIRC3 and cIAP -2 and TNFAIP3 and A20 mRNA expression, indicating that GFPT2 was not required to potentiate NF-kappaB transcription (Additional file 1 : Figure S4B)."
30885209
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"In the case of SW620 cells, a CRC‐derived cell line harboring G12V mutation in K‐Ras gene, it was also observed that the TNFα‐induced expressions of COX‐2, A20, and ICAM1 were not affected by the knockdown of MSK1/2 (Fig. xref )."
31580526
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"However, mutating the O-GlcNAcylation site of c-Rel or treating cells with PUGNAc has no effect on TCR or TNF-α induced expression of TNFAIP3 (encodes TNF-α induced protein 3) and NFKBIA (encodes NF-κB inhibitor α), genes that are considered to contain c-Rel binding sites in their promoters ( xref )."
31198979
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"The acod1 gene was involved in the inhibition of the inflammatory response and acted as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species in lipopolysaccharide-tolerized macrophages [48,49]."
38257883
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"They also found that in HCC cells, miR-18a regulated tumor necrosis factor alpha-induced protein 3 (TNFAIP3) expression."
36945332
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"TNF-α treatment did not induce IFIT1, as expected, and moderately upregulated expression of CXCL10 and TNFAIP3, which was affected by R-HA-NEMO expression, resulting in a very small window (Fig. 1H)."
39853114
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"TNFAIP3 expression (encodes A20) is rapidly induced by TNF-α."
30386338
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"48 , 49 , 50 Here, we show that in MEFs TNF represses the expression of these chemokines through TNF‐induced expression of A20/Tnfaip3, and that this pathway is also highly STAT3 dependent."
35841281
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"Most cells express low levels of A20/Tnfaip3, which is induced by TNF within 30 min by NF‐κB 47 , 63 in concert with STAT3."
35841281
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"We first determined whether the TNFα induced A20 expression in RAW264.7 cells."
25433453
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"These results suggest that TNF induces the expression of NFKBIA and TNFAIP3 independently of c-Rel in Jurkat T cells or that the induction of these genes in response to TNF is mediated by c-Rel that is not GlcNAcylated."
23982206
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"Thirty‐eight genes involved in the defense response to virus, including bone marrow stromal antigen (BST2)/tetherin and MX Dynamin Like GTPase 2/myxovirus resistance protein 2 (MX2) and tumor necrosis factor‐alpha‐induced protein 3 (TNFAIP3) were overexpressed in VKC (Table 1 and Figure 1)."
34390598
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"Irg1 acts as a negative regulator of the TLRs-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages."
38601631
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"The expression of TNFAIP3 is induced by TNF and is involved in the signaling pathway by GPCR."
34504487
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"As expected, JQ1 concomitantly decreased TNF‐stimulated mean expression of both Tnfaip3 and Tnf (Fig 5C, yellow)."
34288498
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"To our knowledge, our study indicates for the first time the up-regulation of TNFAIP3 and A20 gene expression by TNF-alpha through NF-kappaB."
21754991
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"In addition, NISV were found to significantly downregulate LPS-induced genes of this family, including Tnf (TNF-α), TNF induced protein expression of Tnfaip2 and Tnfaip3 and superfamily members Tnfsf4, Tnfsf9 and Tnfsf15 (Fig.  xref )."
39593021
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"The most significant increase in gene expression was of ACOD1; ACOD1 is also called IRG1 and the long non-coding RNA of ACOD1 is involved in the inhibition of the inflammatory response (Luan and Medzhitov, 2016), and also serves as a negative regulator of the TLR-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species in LPS-tolerized macrophages (Li et al., 2013)."
34790908
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"The acceleration in TNFa-induced TNFAIP3 expression in response to hyperthermia could be mediated by the upregulation of NRF2 downstream of the HSR."
38855178
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"Whereas LPS or TNF treatment induced the expression of Tnf, Tnfaip3 and Nfkiab mRNAs, we did not detect upregulation of these genes following ZBP1 or ZBP1ca expression."
38849574
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"As biphasic necroptosis kinetics had indicated that the RelA‐dependent survival mechanism only protected a fraction of cells from premature necroptosis, we asked whether cell‐to‐cell heterogeneity in TNF‐induced A20 expression may be responsible."
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