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TNF increases the amount of TNFAIP3. 22 / 27
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"Because LPS and TNFα induced A20 transcription in macrophages is regulated by Nrf2, we propose that excessive inflammation suppression by Nrf2 is multi-faceted and occurs, at least in part, via A20 dependent termination of NF-κB and MAP kinase signaling."
34073293
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"These results suggest that TNF induces the expression of NFKBIA and TNFAIP3 independently of c-Rel in Jurkat T cells or that the induction of these genes in response to TNF is mediated by c-Rel that is not GlcNAcylated."
23982206
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"The expression of TNFAIP3 is induced by TNF and is involved in the signaling pathway by GPCR."
34504487
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"Strikingly, Gerber’s lab has recently shown that the transcriptional cooperation between GR and NF-κB constitutes the main mechanism explaining the augmentation of TNF-induced A20 expression by dexamethasone (i.e., TNFAIP3, TNF alpha induced protein 3) in airway epithelial and smooth muscle cells ( xref ; xref )."
32473159
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"In primary human airway smooth muscle cells, TNFAIP3 expression was induced by TNF."
28039105
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"TNFα-induced A20 mRNA expression is not further induced by Dex."
29738549
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"In the case of SW620 cells, a CRC‐derived cell line harboring G12V mutation in K‐Ras gene, it was also observed that the TNFα‐induced expressions of COX‐2, A20, and ICAM1 were not affected by the knockdown of MSK1/2 (Fig. xref )."
31580526
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"TNFAIP3 expression (encodes A20) is rapidly induced by TNF-α."
30386338
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"Additionally, GFPT2 expression was not required for TNF induced BIRC3 and cIAP -2 and TNFAIP3 and A20 mRNA expression, indicating that GFPT2 was not required to potentiate NF-kappaB transcription (Additional file 1 : Figure S4B)."
30885209
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"Thirty‐eight genes involved in the defense response to virus, including bone marrow stromal antigen (BST2)/tetherin and MX Dynamin Like GTPase 2/myxovirus resistance protein 2 (MX2) and tumor necrosis factor‐alpha‐induced protein 3 (TNFAIP3) were overexpressed in VKC (Table 1 and Figure 1)."
34390598
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"Together, these data suggest that TNFα signaling via TNFR2 promotes the expression of the anti-inflammatory mediator TNFAIP3/A20, which seems to prevent IL-17A expression in regulatory T cells, as ablation of TNFα signaling suppresses TNFAIP3/A20 and results in increased IL-17A expression in human Treg."
32038615
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"TNF induces TNFAIP3 expression in all tissues including mouse and human intestinal epithelial cells XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
22031828
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"We found that Nrf2 does not regulate TNFα-induced A20 expression in LDMΦs but regulates expression of other genes such as Tnfaip1 and Tnfaip2 ."
34073293
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"Also, the combination of Dex and CpdA does not differentially affect the TNFα-induced expression of A20 and NFKBIA compared to Dex treatment ( xref , xref )."
29738549
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"To our knowledge, our study indicates for the first time the up-regulation of TNFAIP3 and A20 gene expression by TNF-alpha through NF-kappaB."
21754991
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"The most significant increase in gene expression was of ACOD1; ACOD1 is also called IRG1 and the long non-coding RNA of ACOD1 is involved in the inhibition of the inflammatory response (Luan and Medzhitov, 2016), and also serves as a negative regulator of the TLR-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species in LPS-tolerized macrophages (Li et al., 2013)."
34790908
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"To confirm our speculation, we pre-treated the BMDMs with TNFalpha, which could increase the levels of endogenous A20 and TNFAIP3."
32843955
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"As biphasic necroptosis kinetics had indicated that the RelA‐dependent survival mechanism only protected a fraction of cells from premature necroptosis, we asked whether cell‐to‐cell heterogeneity in TNF‐induced A20 expression may be responsible."
33314666
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"Administration of TPT or SN-38, a biological active metabolite of irinotecan [ xref , xref ], strongly interfered with the TNFα-induced expression of IL8 , NFKBIA (NF-κB inhibitor α), TNFAIP3 (TNFα Induced Protein 3) and ICAM1 (intercellular adhesion molecule 1), while inhibition of CXCL2 and CXCL10 expression was less pronounced ( xref C)."
31242600
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"TNFalpha increased the expression of IL6, ICAM1, and TNFAIP3 in both cell lines (XREF_FIG)."
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"As expected, JQ1 concomitantly decreased TNF‐stimulated mean expression of both Tnfaip3 and Tnf (Fig 5C, yellow)."
34288498
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"TNFalpha increased the expression of IL6, ICAM1, and TNFAIP3 in both cell lines."
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