IndraLab

Statements

PARP1 activates BAP1. 6 / 6
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"PARP1 also promotes BAP1 stability via crosstalk between PARylation and ubiquitination."
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"A series of in vitro studies showed that PARP1 stimulated BAP1 activity toward Ub-AMC artificial substrates and that PARylation further enhanced this activity."
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"Interestingly, PARP1 stimulated BAP1 activity toward the physiological substrates of H2Aub that had assembled into a nucleosome, but PARylation completely inhibited this activity and was accompanied by strong BAP1 binding to the nucleosomes."
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"It was proposed that although PARP1 stimulates BAP1 both intrinsically and via PARylation, probably via an allosteric mechanism, PARylated BAP1 formed an unproductive complex with H2A-ub nucleosomes, rendering H2Aub untargetable ."
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"These questions include (1) Does PARP1 stimulate BAP1 within cells, and how is this activity regulated during CPD repair?"
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"(4) Does PARP1-mediated BAP1 PARylation exert an effect on DSB repair in which PARP1 plays an important role ."
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