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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to DNM1L activates TP53. 1 / 1

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"Cytoplasmic p53 binds to Drp1 and induces co-accumulation of Drp1 and p53 at mitochondria, leading to Drp1 hyperactivation and subsequent excessive mitochondrial fission and dysfunction (ROS production, loss of DeltaPsim) and neuronal necrosis."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...